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NeuroScientific Biopharmaceuticals (ASX:NSB) - Managing Director & CEO, Matthew Liddelow - The Market Herald
Managing Director & CEO, Matthew Liddelow
Source: TechInvest Magazine
  • Neuroscientific Biopharmaceuticals (NSB) has confirmed positive results from testing of the company's EmtinB drug in Multiple Sclerosis
  • The study compared EmtinB to Copaxone — a market-leading treatment for MS with sales around $US4 billion (around A$5.6 billion) annually
  • EmtinB was shown to be 25 to 30 per cent more effective in regenerating protective nerve coatings that are damaged in MS sufferers
  • It also acted to increase the survival of neuronal cells and enabled the regeneration of nerve cell axons — both effects absent in Copaxone
  • There's a long testing and regulatory road ahead before EmtinB could be commercialised, but the preliminary results augur very well for NSB
  • Neuroscientific Biopharmaceuticals closed Tuesday's session 4.2 per cent lower at 23 cents

Neuroscientific Biopharmaceuticals (NSB) has confirmed positive final results from a trial testing its EmtinB drug in Multiple Sclerosis (MS).

The in vitro study (performed on cells in a test tube rather than in a living organism) compared EmtinB against market-leading drug, Copaxone. The study was conducted by independent contract research organisation Neuron Experts in France.

A new contender

MS is a degenerative disorder resulting from the loss of a protective covering around nerve cell axons. The myelin sheath insulates nerve cell axons and is essential for normal cognitive, sensory, and motor function.

Loss of the protective myelin sheath results in deterioration of nerve cells, and the according degeneration in sensory and motor function.

The results of the comparison study augur very well for EmtinB and NSB.

Copaxone is a leading therapeutic treatment for MS that generates annual sales of around US$4 billion (around A$5.6 billion). The study showed EmtinB to be more effective than Copaxone across three key metrics.

Not only did EmtinB have a significant effect on increasing the myelination of neuronal cell axons, it also increased the survival of neuronal cells and enabled the regeneration of nerve cell axons.

The fact EmtinB outperformed Copaxone in myelin formation by 25 to 30 per cent (depending on dosage) is a big win. But given Copaxone has no noticeable effect on either cell survival or axonal regeneration, the multi-efficacy of EmtinB is potentially of huge significance to both NSB and sufferers of MS worldwide.

CEO and Managing Director of NeuroScientific Biopharmaceuticals, Matthew Liddelow says the results are a step forward for the company.

"This positive data is significantly indicative of the disease modifying potential of EmtinB as a treatment for Multiple Sclerosis," Matthew said.

"Validation of the positive effect of EmtinB treatment of nerve cell survival, regeneration and remyelination means EmtinB has the potential to be a highly effective treatment for this severe chronic disease," he concluded.

Next steps

NSB is developing a suite of peptide-based pharmaceutical drugs similar to EmtinB that target a number of neurodegenerative conditions.

EmtinB was originally aimed at treating Alzheimer’s disease and glaucoma, but these preliminary results for MS are also proving highly promising.

The company will continue studies on EmtinB and similar compounds (EmtinAc, EmtinAn, and EmtinBn) which have demonstrated similar therapeutic potential as EmtinB, in the hope of treating conditions with high unmet medical demand.

The company had almost $3.3 million in the bank at the end of June. It'll be interesting to see how quickly work can progress in the continued testing and study of these novel peptides which have shown such preliminary promise.

Neuroscientific Biopharmaceuticals closed Tuesday's session 4.2 per cent lower at 23 cents.


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